BEGIN:VCALENDAR VERSION:2.0 PRODID:-//linuxsoftware.nz//NONSGML Joyous v1.4//EN BEGIN:VEVENT SUMMARY:A novel compact gas-based nanodosimeter detector for proton therap y applications DTSTART:20250130T150000Z DTEND:20250130T170000Z DTSTAMP:20260905T220653Z UID:00b49cc7-aadc-4e7c-ab30-33e582b65891 SEQUENCE:2 CREATED:20250129T091614Z DESCRIPTION:The major goal in the metrology of micro- or nanodosimetry is to provide physical quantities that are well suited to represent the biolo gical effectiveness of radiation\, to model it\, and assess it by measurem ent. Absorbed dose\, which has been consistently used in "\;macroscopi c"\; dosimetry up to now\, turns out to be unsuitable when applied to the microscale\; for example\, when modeling radiation effects on cells an d DNA. Especially for densely ionizing particles such as low energy proton s\, ionization clusters occur on the nanometer scale. The quantity conside red suitable for nanodosimetry is the ionization cluster size distribution \, i.e.\, the probability distribution of ionization cluster sizes. From a metrological point of view\, nanodosimeters are used to determine the ion ization cluster size distributions produced by the mixed radiation field.T here is an urgent need to measure and predict the formation of large ioniz ation clusters\, which are biologically most important\, using a gas-based compact nanodosimeter as well as Monte Carlo track-structure simulations. Nanodosimetric quantities might replace or complement the dosimetric quan tities currently in use\, and could then be used in treatment planning and radiation protection. Thus\, further design and testing of a compact nano dosimeter for mixed radiation fields is the objective of this work. LAST-MODIFIED:20250129T091639Z LOCATION:Online URL:http://df.vps.tecnico.ulisboa.pt/pt/eventos/a-novel-compact-gas-based- nanodosimeter-detector-for-proton-therapy-applications/ X-ALT-DESC;FMTTYPE=text/html:

The major goal in t he metrology of micro- or nanodosimetry is to provide physical quantities that are well suited to represent the biological effectiveness of radiatio n\, to model it\, and assess it by measurement. Absorbed dose\, which has been consistently used in "\;macroscopic"\; dosimetry up to now\, turns out to be unsuitable when applied to the microscale\; for example\, when modeling radiation effects on cells and DNA.

Especially for densely ionizing particles such as low energy protons\, ionization cluste rs occur on the nanometer scale. The quantity considered suitable for nano dosimetry is the ionization cluster size distribution\, i.e.\, the probabi lity distribution of ionization cluster sizes. From a metrological point o f view\, nanodosimeters are used to determine the ionization cluster size distributions produced by the mixed radiation field.

There is an urgent need to measure and predict the formation of large ionization clust ers\, which are biologically most important\, using a gas-based compact na nodosimeter as well as Monte Carlo track-structure simulations. Nanodosime tric quantities might replace or complement the dosimetric quantities curr ently in use\, and could then be used in treatment planning and radiation protection. Thus\, further design and testing of a compact nanodosimeter f or mixed radiation fields is the objective of this work.

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