BEGIN:VCALENDAR VERSION:2.0 PRODID:-//linuxsoftware.nz//NONSGML Joyous v1.4//EN BEGIN:VEVENT SUMMARY:A novel treatment planning method for proton FLASH radiotherapy: Combining FLASH with VMAT DTSTART:20230919T140000Z DTEND:20230919T160000Z DTSTAMP:20260813T105707Z UID:10061ea1-f787-4eb1-a28a-34b6f1a80ef8 SEQUENCE:1 CREATED:20230911T210338Z DESCRIPTION: In this work\, we propose a new treatment planning method for multi-beam FLASH radiotherapy (Stitching FLASH) that combines FLASH deli vered by proton beams\, with volumetric modulated arc therapy (VMAT). The Stitching FLASH method requires the target to be divided into different se ctions. For sections close to an Organ-at-risk (OAR)\, proton FLASH beams were used to deliver radiation dose. For the remaining target volume\, V MAT was used to achieve optimal target coverage. To validate the Stitchin g FLASH method\, we used matRad\, a treatment planning toolkit developed by DKFZ. We applied it first\, as proof of concept\, to irradiate three sp herical phantoms surrounded by several OARs and second\, to irradiate a c ervical spinal cord tumor\, which we then compared to the clinical VMAT p lan. In our phantoms study\, we managed to fulfil the minimum dose and dos e-rate conditions for protecting the OARs with FLASH\, while obtaining ex cellent target coverage and superb dose conformity and homogeneity. For t he spinal cord tumor irradiation\, we were able to significantly increase the Clinical Target Volume (CTV) coverage and minimum dose\, while keepin g the doses in the OARs below the clinical thresholds using the FLASH pro tecting effect. With the novel FLASH treatment planning method proposed in this work\, we have demonstrated that it is possible to protect critical OARs\, while maintaining excellent target coverage and dose homogeneity\, as well as conformity. This shows that the Stitching FLASH method is pro mising for proton FLASH radiotherapy LAST-MODIFIED:20230911T210338Z LOCATION:Online URL:http://df.vps.tecnico.ulisboa.pt/pt/eventos/a-novel-treatment-planning -method-for-proton-flash-radiotherapy-combining-flash-with-vmat/ X-ALT-DESC;FMTTYPE=text/html:

In this work\, we propose a new treatment planning method for multi-beam FLASH radiotherapy (Stitching FLASH) that combines FLASH delivered by proton beams\, with vo lumetric modulated arc therapy (VMAT). The Stitching FLASH method requires the target to be divided into different sections. For sections close to an Organ-at-risk (OAR)\, proton FLASH beams were used to deliver radiatio n dose. For the remaining target volume\, VMAT was used to achieve optimal target coverage. To validate the Stitching FLASH method\, we used matRad \, a treatment planning toolkit developed by DKFZ.

We applied i t first\, as proof of concept\, to irradiate three spherical phantoms sur rounded by several OARs and second\, to irradiate a cervical spinal cord tumor\, which we then compared to the clinical VMAT plan. In our phantoms study\, we managed to fulfil the minimum dose and dose-rate conditions fo r protecting the OARs with FLASH\, while obtaining excellent target cover age and superb dose conformity and homogeneity.

For the spinal c ord tumor irradiation\, we were able to significantly increase the Clinic al Target Volume (CTV) coverage and minimum dose\, while keeping the doses in the OARs below the clinical thresholds using the FLASH protecting eff ect. With the novel FLASH treatment planning method proposed in this work\ , we have demonstrated that it is possible to protect critical OARs\, whi le maintaining excellent target coverage and dose homogeneity\, as well as conformity. This shows that the Stitching FLASH method is promising for proton FLASH radiotherapy

END:VEVENT END:VCALENDAR