BEGIN:VCALENDAR VERSION:2.0 PRODID:-//linuxsoftware.nz//NONSGML Joyous v1.4//EN BEGIN:VEVENT SUMMARY:Design and validation of microfluidic structures on a Lab-on-a-CD for biomedical diagnosis DTSTART:20250707T160000Z DTEND:20250707T180000Z DTSTAMP:20260906T110311Z UID:9da4cb70-9a94-49cb-914a-549a083442d3 SEQUENCE:2 CREATED:20250707T081943Z DESCRIPTION:Microfluidic devices are crucial in biomedical research\, enab ling precise manipulation of small fluid volumes for diagnostics and drug delivery. Advances in materials and fabrication techniques have sig- nific antly improved their performance. This thesis focuses on developing and op timizing a pneumatic siphon in a microfluidic system using advanced thermo plastics and precise CNC milling.Polymethyl Methacrylate (PMMA) was chosen for its optical clarity\, strength\, and cost-effectiveness\, ideal for m icrofluidic applications. Initial designs were crafted in AutoCAD and refi ned with 3D modeling and simulations in Fusion 360\, ensuring meticulous t ool selection and parameter optimization. The primary challenge was achiev ing accurate fluid flow and priming within the pneumatic siphon.The main r esult of this research was the valuable learning curve associated with mic rofluidic design and manufacturing. This study underscores the importance of iterative testing and precise engineering in microfluidic device develo pment\, revealing that practical adjustments are often needed for optimal performance. The research validates PMMA and advanced CAD/CAM tools in mic rofluidic fabrication\, emphasizing the need for continuous refinement in design processes.In a broader context\, this study contributes to a method ology for pneumatic structures design and optimization\, enhancing microfl uidic system reliability and efficiency for scientific and medical applica - tions. This work highlights the critical role of material selection\, pr ecise engineering\, and iterative testing in advancing microfluidic techno logies\, providing insights applicable across various disciplines. LAST-MODIFIED:20250707T082204Z LOCATION:Anfiteatro QA1.1\, Piso 1\, Pavilhão de Química\, Campus Alamed a URL:http://df.vps.tecnico.ulisboa.pt/pt/eventos/design-and-validation-of-m icrofluidic-structures-on-a-lab-on-a-cd-for-biomedical-diagnosis/ X-ALT-DESC;FMTTYPE=text/html:

Microfluidic device s are crucial in biomedical research\, enabling precise manipulation of sm all fluid volumes for diagnostics and drug delivery. Advances in materials and fabrication techniques have sig- nificantly improved their performanc e. This thesis focuses on developing and optimizing a pneumatic siphon in a microfluidic system using advanced thermoplastics and precise CNC millin g.

Polymethyl Methacrylate (PMMA) was ch osen for its optical clarity\, strength\, and cost-effectiveness\, ideal f or microfluidic applications. Initial designs were crafted in AutoCAD and refined with 3D modeling and simulations in Fusion 360\, ensuring meticulo us tool selection and parameter optimization. The primary challenge was ac hieving accurate fluid flow and priming within the pneumatic siphon.
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The main result of this research was the valu able learning curve associated with microfluidic design and manufacturing. This study underscores the importance of iterative testing and precise en gineering in microfluidic device development\, revealing that practical ad justments are often needed for optimal performance. The research validates PMMA and advanced CAD/CAM tools in microfluidic fabrication\, emphasizing the need for continuous refinement in design processes.

In a broader context\, this study contributes to a method ology for pneumatic structures design and optimization\, enhancing microfl uidic system reliability and efficiency for scientific and medical applica - tions. This work highlights the critical role of material selection\, pr ecise engineering\, and iterative testing in advancing microfluidic techno logies\, providing insights applicable across various disciplines.

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