BEGIN:VCALENDAR VERSION:2.0 PRODID:-//linuxsoftware.nz//NONSGML Joyous v1.4//EN BEGIN:VEVENT SUMMARY:Simulation-based optimization of the Depth-of-Interaction determin ation capability of a PET scanner DTSTART:20251203T110000Z DTEND:20251203T130000Z DTSTAMP:20260906T115017Z UID:afbda553-1b7a-4aa4-b148-7f10156aa07a SEQUENCE:4 CREATED:20251125T094301Z DESCRIPTION:Cancer encompasses over a hundred diseases characterized by th e uncontrolled proliferation of abnormal cells. Proton therapy enables pre cise tumor targeting while minimizing damage to healthy tissue\, yet its e ffectiveness depends on accurate proton range verification. Among the avai lable methods\, Positron Emission Tomography (PET) is preferred for provid ing real-time\, three-dimensional imaging and dosimetric information durin g treatment. Incorporating depth-of-interaction (DoI) measurement in PET s canners improves spatial resolution and reduces parallax errors\, particul arly at the periphery of the scanner. This study aimed to optimize\, using simulation-based methods\, the DoI determination capability of a dual-end ed readout PET detection module. The module was modeled using the ANTS3 si mulation toolkit. It consisted of a Lutetium–yttrium oxyorthosilicate (L YSO) scintillator with a 3 × 3 mm² cross-section and 30 mm length\, coup led to two Hamamatsu S14161-3050HS-08 Silicon Photomultiplier (SiPM) senso rs. The scintillator was encapsulated with an Enhanced Specular Reflector (ESR) film. The model was validated using available experimental data on t he DoI resolution\, showing sufficient predictive power. The optimization conducted in this study improved the DoI resolution by about 54% and up to 86% at the center and edges of the scintillator\, respectively\, compared to the initial configuration. This improvement was achieved by introducin g an optical grease coupling between the scintillator and the sensors\, im plementing scintillator encapsulation with Lambertian scattering\, and usi ng a higher-efficiency SiPM sensor. A case study was also conducted to ana lyze the effect of scintillator size on the module'\;s DoI determinati on capability. Retro-reflector scintillator encapsulation was identified a s a promising option for future investigation. LAST-MODIFIED:20251127T091651Z LOCATION:Online URL:http://df.vps.tecnico.ulisboa.pt/pt/eventos/simulation-based-optimizat ion-of-the-depth-of-interaction-determination-capability-of-a-pet-scanner/ X-ALT-DESC;FMTTYPE=text/html:

Cancer encompasses over a hundred diseases characterized by the uncontrolled proliferation of abnormal cells. Proton therapy enables precise tumor targeting while mini mizing damage to healthy tissue\, yet its effectiveness depends on accurat e proton range verification. Among the available methods\, Positron Emissi on Tomography (PET) is preferred for providing real-time\, three-dimension al imaging and dosimetric information during treatment. Incorporating dept h-of-interaction (DoI) measurement in PET scanners improves spatial resolu tion and reduces parallax errors\, particularly at the periphery of the sc anner.

This study aimed to optimize\, using simulation-based met hods\, the DoI determination capability of a dual-ended readout PET detect ion module. The module was modeled using the ANTS3 simulation toolkit. It consisted of a Lutetium–yttrium oxyorthosilicate (LYSO) scintillator wit h a 3 × 3 mm² cross-section and 30 mm length\, coupled to two Hamamatsu S14161-3050HS-08 Silicon Photomultiplier (SiPM) sensors. The scintillator was encapsulated with an Enhanced Specular Reflector (ESR) film.

The model was validated using available experimental data on the DoI reso lution\, showing sufficient predictive power. The optimization conducted i n this study improved the DoI resolution by about 54% and up to 86% at the center and edges of the scintillator\, respectively\, compared to the ini tial configuration. This improvement was achieved by introducing an optica l grease coupling between the scintillator and the sensors\, implementing scintillator encapsulation with Lambertian scattering\, and using a higher -efficiency SiPM sensor. A case study was also conducted to analyze the ef fect of scintillator size on the module'\;s DoI determination capabili ty. Retro-reflector scintillator encapsulation was identified as a promisi ng option for future investigation.

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